Phagocytes in macrovascular pathophysiology
Institute for Cardiovascular Prevention
Ludwig-Maximilians University Munich
80336 Munich, Germany
tel +49 89 5160 4673
fax +49 89 5160 4352
Atherosclerosis is a chronic inflammatory disorder of large arteries. Following initial endothelial dysfunction, leukocytes start to infiltrate the arterial vessel wall contributing to lumen narrowing and ultimately to plaque rupture clinically evident as myocardial infarction or stroke. Bone marrow- and spleen-derived myeloid cells such as monocytes and neutrophils are crucially involved in atherogenesis, atheroprogression, and atherothrombosis. Our group focuses on recruitment of monocyte subsets and neutrophils to large arteries and on the investigation of pro-atherogenic mechanisms promoted by these cell types.
Left to right: Oliver Soehnlein, MD, PhD, group leader; Jean-Eric Alard, PhD, post-doc; Patricia Lemnitzer, Lab tech; Henrick Friese, doctoral student; Claudia Geissler, Lab tech; Sarawuth Wantha, MSc, PhD student; Maik Drechsler, PhD, post-doc; Almudena Ortega-Gomez, PhD, post-doc; Helene Hartwig, MSc, PhD student; Jürgen Pyta, MSc, PhD student (with Dr. Remco Megens); Klaus Kemmerich, MSc, PhD student.
Soehnlein O. The multiple roles of neutrophils in atherosclerosis.
Circ Res, in press.
Döring Y, Drechsler M, Vijayan S, Kemmerich K, Wantha S, Weber C, Gallo RL, Soehnlein O. Neutrophil-derived cathelicidin promotes atherosclerotic lesion formation
Circ Res, in press.
Megens RTA, Vijayan S, Lievens D, Döring Y, Lutgens E, van Zandvoort M, Grommes J, Weber C, Soehnlein O. Presence of neutrophil extracellular traps in atherosclerotic lesions
Thromb Haemost,2012; 107:597-8.
Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O. Disruption of platelet-derived chemokine heteromers abolishes endotoxin-induced lung injury
Am J Resp Crit Care Med, 2012; 185:628-36.
Soehnlein O, Wantha S, Simsekyilmaz S, Döring Y, Megens RTA, Mause SF, Drechsler M, Smeets R, Weinandy S, Schreiber F, Gries T, Vijayan S, van Zandvoort MAMJ, Agerberth B, Pham CT, Gallo RL, Hackeng T, Liehn EA, Zernecke A, Klee D, Weber C, Neutrophil-derived cathelicidin protects from neointimal hyperplasia
Sci Transl Med, 2011; 3:103ra98.
Drechsler M, Megens RTA, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis.
Circulation, 2010; 122:1837-45.
Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation.
Nat Rev Immunol. 2010; 10:427-39.
Soehnlein O, Kai-Larsen Y, Frithiof R, Sorensen OE, Kenne E, Scharffetter-Kochanek K, Eriksson EE, Herwald H, Agerberth B, Lindbom L. Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.
J Clin Invest. 2008; 118:3491-502.
Soehnlein O, Zernecke A, Eriksson EE, Rothfuchs AG, Pham CT, Herwald H, Bidzhekov K, Rottenberg ME, Weber C, Lindbom L. Neutrophil secretion products pave the way for inflammatory monocytes.
Blood. 2008; 112:1461-71.